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Pod tuto nodu budeme dávať prehľad noviniek farmakoterapie COVID 19

Asi najlepsi prehlad noviniek: http://cafepharma.com/covid-19

Lieky a vakciny - prehlad




0000010108333809087030870872303808826066
imnot
 imnot      09.01.2021 - 18:16:52 , level: 1, UP   NEW
...Sa ukazuju ako vhodna volba liecby (preprint):
https://www.medrxiv.org/content/10.1101/2021.01.07.21249390v1.full.pdf

In critically ill patients with Covid-19 receiving organ support in intensive care, treatment with the IL-6 receptor antagonists, tocilizumab and sarilumab, improved outcome, including survival. (ClinicalTrials.gov number: NCT02735707)

0000010108333809087030870872303808824759
imnot
 imnot      06.01.2021 - 11:01:43 (modif: 06.01.2021 - 11:02:04) [8K] , level: 1, UP   NEW !!CONTENT CHANGED!!
S pomocou AI sa podarilo najst molekulu medzi farmakami, ktora by mohla mat efekt:
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients

a naozaj ma:
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

Uz sa podava aj u nas, ale je problem s dostupnostou

0000010108333809087030870872303808811471
Faust
 Faust      27.11.2020 - 21:01:19 , level: 1, UP   NEW
Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial
https://www.medrxiv.org/content/10.1101/2020.10.30.20217364v3.full?fbclid=IwAR2WDn-9ibdBij4GoFekwzvqDHDowFuHBUmJDvUm3z-cdSgOCJnKhadhmwE

0000010108333809087030870872303808794250
imnot
 imnot      13.10.2020 - 17:11:51 (modif: 13.10.2020 - 17:12:01) [3K] , level: 1, UP   NEW !!CONTENT CHANGED!!
double-blinded, randomized, placebo controlled studia potvrdzuje ucinnost remdesiviru

Our data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.
https://www.nejm.org/doi/full/10.1056/NEJMoa2007764?query=featured_coronavirus&fbclid=IwAR1DeT4G47S1OiV__aUEITRxXGXtnFO6mCOdjVieZe9p2hOCJVqVT8VQ6b8

000001010833380908703087087230380879425008794433
mirex
 mirex      14.10.2020 - 09:23:54 (modif: 14.10.2020 - 09:24:08), level: 2, UP   NEW !!CONTENT CHANGED!!
Vyberiem odtial podla mna dolezitu TLDR informaciu:

nejmoa2007764_f2.jpeg

Takze o trochu (o par percent) to zlepsi priebeh (v mnohych pripadoch ale nie v tazkych na ventilacii), ale nie je to zazracny liek ktory chorobu vylieci.

00000101083338090870308708723038087942500879443308794493
jolly good
 jolly good      14.10.2020 - 11:02:10 , level: 3, UP   NEW
takto bezne vyzeraju tie krivky medzi ucinnym liekom vs placebo?

0000010108333809087030870872303808794250087944330879449308794500
blurec
 blurec      14.10.2020 - 11:13:50 , level: 4, UP   NEW
z mojho pohladu ako laika - ano.

0000010108333809087030870872303808782627
imnot
 imnot      06.09.2020 - 11:24:10 , level: 1, UP   NEW
Firma Novovax vydala v NEJM výsledky fáze I-II. Jejich vakcína NVX-CoV2373 je dobře imunogenní.
https://www.nejm.org/doi/full/10.1056/NEJMoa2026920

0000010108333809087030870872303808779170
Thunder Perfect Mind
 Thunder Perfect Mind      22.08.2020 - 16:04:46 , level: 1, UP   NEW
https://medicine.wustl.edu/news/nasal-vaccine-against-covid-19-prevents-infection-in-mice/

0000010108333809087030870872303808770735
Thunder Perfect Mind
 Thunder Perfect Mind      20.07.2020 - 10:40:06 [1K] , level: 1, UP   NEW
https://www.bbc.com/news/health-53467022

0000010108333809087030870872303808761184
Thunder Perfect Mind
 Thunder Perfect Mind      16.06.2020 - 21:54:55 , level: 1, UP   NEW
https://www.bbc.com/news/health-53061281

0000010108333809087030870872303808752908
Thunder Perfect Mind
 Thunder Perfect Mind      23.05.2020 - 15:53:24 , level: 1, UP   NEW
Vysla studia k Remdesiviru, tldr: pomaha ale nie ked sa nasadi pacientom uz vo velmi zlom stave. Som zvedavy na dalsie studie.

Overall remdesivir is a safe and effective drug for #COVID19 patients with lower respiratory tract involvement. Review of the data supports the drug's potential for promoting survival. For all patients enrolled, the 30%⬇️ deaths is consistent in direction and magnitude as the ⬆️ 27% recovery time.
Patients w/ most severe baseline status derived no benefit.
https://twitter.com/EricTopol/status/1263958776169693184

0000010108333809087030870872303808752606
Thunder Perfect Mind
 Thunder Perfect Mind      22.05.2020 - 17:19:37 , level: 1, UP   NEW
dalsie ockovanie, non-replicating adenovirus type-5 (Ad5) vectored COVID-19 vaccine
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31208-3/fulltext

0000010108333809087030870872303808751290
Thunder Perfect Mind
 Thunder Perfect Mind      19.05.2020 - 15:34:18 , level: 1, UP   NEW
https://www.globaltimes.cn/content/1188719.shtml
https://www.cell.com/cell/fulltext/S0092-8674(20)30620-6

0000010108333809087030870872303808750938
Thunder Perfect Mind
 Thunder Perfect Mind      18.05.2020 - 20:21:25 [5K] , level: 1, UP   NEW
https://www.statnews.com/2020/05/18/early-data-show-moderna-covid-19-vaccine-generates-immune-response/

0000010108333809087030870872303808748953
Thunder Perfect Mind
 Thunder Perfect Mind      12.05.2020 - 23:02:56 , level: 1, UP   NEW
https://racap.com/covid-19

0000010108333809087030870872303808747826
Thunder Perfect Mind
 Thunder Perfect Mind      09.05.2020 - 07:12:37 , level: 1, UP   NEW
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31042-4/fulltext

0000010108333809087030870872303808747684
imnot
 imnot      08.05.2020 - 15:30:57 , level: 1, UP   NEW
V japonsku remdesivir ako liek na covid:
https://www.reuters.com/article/us-health-coronavirus-japan-remdesivir/japan-approves-gilead-sciences-remdesivir-as-covid-19-drug-idUSKBN22J1UZ?feedType=RSS&feedName=healthNews

0000010108333809087030870872303808747135
Thunder Perfect Mind
 Thunder Perfect Mind      06.05.2020 - 19:25:35 [1K] , level: 1, UP   NEW
https://science.sciencemag.org/content/early/2020/05/05/science.abc1932.full

0000010108333809087030870872303808742619
imnot
 imnot      23.04.2020 - 20:01:35 (modif: 23.04.2020 - 20:02:41) [1K] , level: 1, UP   NEW !!CONTENT CHANGED!!
heh
Gilead's drug Remdesivir has "flopped" in its first trial, according to the Financial Times

src (paywall): https://www.ft.com/content/0a4872d1-4cac-4040-846f-ce32daa09d99
https://twitter.com/covidperspectiv/status/1253364270286270466

000001010833380908703087087230380874261908742860
imnot
 imnot      24.04.2020 - 12:19:39 , level: 2, UP   NEW
WHO unikla data očekávané čínské studie (RCT) Remdesiviru

data pochází ze screenshotu z webu WHO s krátkým shrnutím studie bez podrobností (viz. článek)
237 pacientů s potvrzeným COVID-19 s těžkým průběhem
158 dostalo Remdesivir, 78 dostalo placebo
nebyl rozdíl v rychlosti klinického zlepšení ve srovnání se standartní péčí
po 30 dnech zemřelo 13,9% pacientů, kteří dostali Remdesivir a 12,8% v kontrolní skupině (rozdíl není statisticky signifikantní)
Remdesivir byl předčasně ukončen u 18 pacientů (11,6%) vs. placebo u 4 (5,1%) kvůli nežádoucím účinkům
celkově byly popisovány nežádoucí účinky u 65,2% pacientů s Remdesivirem vs. u 64,1% pacientů s placebem
studie ukončena předčasně pro nedostatek pacientů (původní plán 453 účastníků)
celkově WHO hodnotí studii negativně: "léčba Remdesivirem, nebyla asociována s klinickými či virologickými benefity"
Gilead nesouhlasí s hodnocením/charakteristikou studie, kterou zveřejnila WHO (viz. článek)

Více info a kritické připomínky k hodnocenív článku https://www.statnews.com/2020/04/23/data-on-gileads-remdesivir-released-by-accident-show-no-benefit-for-coronavirus-patients/
Info o studii z webu NIH - https://clinicaltrials.gov/ct2/show/NCT04257656

0000010108333809087030870872303808738263
Thunder Perfect Mind
 Thunder Perfect Mind      10.04.2020 - 22:55:42 [1K] , level: 1, UP   NEW
Results from a cohort analysis of 53 patients hospitalized with severe complications of COVID-19 who were treated with the investigational antiviral remdesivir on an individual compassionate use basis.

Nearly two thirds of patients (64 percent, n=34/53) in this cohort were on mechanical ventilation at baseline, including four patients also on extracorporeal membrane oxygenation (ECMO). Treatment with remdesivir resulted in an improvement in oxygen support class for 68 percent of patients (n=36/53) over a median follow-up of 18 days from the first dose of remdesivir. More than half of patients on mechanical ventilation were extubated (57 percent, n=17/30) and nearly half of all patients (47 percent, n=25/53) were discharged from the hospital following treatment with remdesivir. After 28 days of follow-up, the cumulative incidence of clinical improvement, defined as discharge from the hospital and/or at least a two-point improvement from baseline on a predefined six-point scale, was 84 percent according to Kaplan-Meier analysis. Clinical improvement was less frequent among patients on invasive ventilation versus noninvasive ventilation (HR: 0.33 [95 percent CI 0.16, 0.68]) and among patients at least 70 years of age (HR vs < 50 years: 0.29 [95 percent CI 0.11, 0.74]). Compassionate use data have limitations due to the small size of the cohort, the relatively short duration of follow-up, potential missing data due to the nature of the program and lack of a randomized control group.
https://www.gilead.com/news-and-press/press-room/press-releases/2020/4/data-on-53-patients-treated-with-investigational-antiviral-remdesivir-through-the-compassionate-use-program-published-in-new-england-journal-of-medici

0000010108333809087030870872303808737481
Thunder Perfect Mind
 Thunder Perfect Mind      08.04.2020 - 19:49:52 [1K] , level: 1, UP   NEW
https://stm.sciencemag.org/content/early/2020/04/03/scitranslmed.abb5883

000001010833380908703087087230380873748108737558
blurec
 blurec      08.04.2020 - 22:33:29 , level: 2, UP   NEW
Painter says he started working on the antiviral drug in 2013 after he was approached by the Defense Threat Reduction Agency. At the time, the federal agency was looking for a way to fight Venezuelan equine encephalitis, a sometimes-fatal viral disease that causes brain swelling.

...

Painter says federal agencies have put $35 million into researching the drug since 2013. He says it could be ready for human testing by mid-April.

...

And the verdict is still out on whether Emory’s EIDD 2801 or any other medication is effective in treating COVID-19. The FDA has not approved any drug to treat any coronavirus.

(11.2.2020) https://www.wabe.org/emory-researchers-think-they-have-a-drug-to-fight-the-new-coronavirus/

0000010108333809087030870872303808737119
repelent
 repelent      08.04.2020 - 10:18:56 , level: 1, UP   NEW
Researchers have found that an anti-parasitic drug already available around the world can kill the novel coronavirus grown in cell cultures within 48 hours, an advance that may lead to the development and trial of a new clinical therapy for COVID-19.
https://www.deccanherald.com/science-and-environment/anti-parasitic-drug-kills-coronavirus-in-lab-grown-cells-study-821458.html

0000010108333809087030870872303808736167
imnot
 imnot      06.04.2020 - 21:01:34 , level: 1, UP   NEW
https://golden.com/wiki/Cluster%3A_COVID-19-ZXJX9AR#COVID-19-treatments-and-vaccines_Lists-of-potential-treatments-vaccines-and-diagnostics-of-COVID-19-in-development


prehald liekov a vakcin

0000010108333809087030870872303808735433
Thunder Perfect Mind
 Thunder Perfect Mind      05.04.2020 - 11:35:15 [1K] , level: 1, UP   NEW
https://www.acsh.org/news/2020/03/26/problem-remdesivir-making-it-14665

0000010108333809087030870872303808729567
imnot
 imnot      24.03.2020 - 11:57:32 (modif: 24.03.2020 - 11:59:27), level: 1, UP   NEW !!CONTENT CHANGED!!
https://www.fiercepharma.com/pharma/abbvie-gives-up-patent-rights-to-hiv-med-kaletra-amid-covid-19-tests-report

Pekne, abbvie sa vzdala vlastnických práv na liek. prípravok Kaletra (Lopinavir/ritonavir), slúźiaci k tlmeni prehnanej imunitnej odpovede, ćo znamená, že ostatné farma firmy môžu začat vyrábať generika (liek bude teda lacnejší).

Okrem toho z článku:
Even with a suite of clinical trials ongoing, at least one small-scale study has argued Kaletra is not effective in treating COVID-19.

Data from a Chinese study showed Kaletra, a combination of antiviral drugs lopinavir and ritonavir, failed across the board in a 199-patient clinical trial. It didn’t top standard of care at improving clinical symptoms, extending life span or cutting viral shedding in patients hospitalized with severe COVID-19, results from a study published Wednesday in The New England Journal of Medicine showed.

0000010108333809087030870872303808729084
SYNAPSE CREATOR
 Heaven and Hell      23.03.2020 - 14:40:36 [5K] , level: 1, UP   NEW  HARDLINK
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

zoznam 69 latok, ktore by mohli byt uzitocne pri liecbe COVID-19. medzi nimi aj haloperidol :)

0000010108333809087030870872303808728207
Thunder Perfect Mind
 Thunder Perfect Mind      21.03.2020 - 16:49:31 , level: 1, UP   NEW
https://www.medrxiv.org/content/10.1101/2020.03.17.20037432v1

0000010108333809087030870872303808728174
imnot
 imnot      21.03.2020 - 14:48:09 , level: 1, UP   NEW
https://twitter.com/GaetanBurgio/status/1241201751916568576

Analýza limito štúdie.

Conclusion:
"In short, all this hype on the clinical trial is based on a open label, non randomized and underpowered clinical trial on HCQ treatment against #COVID19 with viral load as an outcome that was not properly measured in 2/3 of the control cohort !!!"

0000010108333809087030870872303808728129
imnot
 imnot      21.03.2020 - 13:18:33 , level: 1, UP   NEW
The COVID-19 pandemic caused by SARS-CoV-2 is a global health emergency. An attractive drug target among coronaviruses is the main protease (Mpro, 3CLpro), due to its essential role in processing the polyproteins that are translated from the viral RNA. We report the X-ray structures of the unliganded SARS-CoV-2 Mpro and its complex with an α-ketoamide inhibitor. This was derived from a previously designed inhibitor but with the P3-P2 amide bond incorporated into a pyridone ring to enhance the half-life of the compound in plasma. Based on the structure, we developed the lead compound into a potent inhibitor of the SARS-CoV-2 Mpro. The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route.
https://science.sciencemag.org/content/early/2020/03/19/science.abb3405?fbclid=IwAR3DuJi_OCZRfPZLA8msR-klp2FKVshYx78W9R6seVpH8AF0zVeUDNdt_r8