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Interaction between DRD2 and AKT1 genetic variations on risk of psychosis in cannabis users: a case–control study

nasli spojitost medzi rizikovymi alelami dvoch genov a konzumaciou marihuany.

Our results indicate a model of interaction known as ‘qualitative G×E interaction’ with a crossover pattern: carriers of risk allele(s) for one of the two genes (DRD2 rs1076560 T or AKT1 rs2494732 C allele), compared with individuals carrying no ‘risk’ alleles (DRD2 rs1076560 GG/AKT1 rs2494732 TT), have a lower probability of psychotic disorder if they never used cannabis but a higher probability if they have a history of cannabis use, especially of daily use.

cnbs2.png
cnbs1.png
Y os je odds ratio

sauce:
http://www.nature.com/articles/npjschz201525?WT.mc_id=FBK_SCHZ_1507_201525

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